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Archive for November, 2007

Over the Counter Pain Medication May Reduce the Risk of Parkinson’s

Tuesday, November 13th, 2007

otc.jpg ”Given our results and the growing burden of Parkinson’s disease as people age, there’s a pressing need for further studies explaining why these drugs may play a protective role,” said study author Angelika D. Wahner, PhD, with the UCLA School of Public Health in Los Angeles.

The study involved 579 men and women, half of whom had Parkinson’s disease. The participants were asked if they had taken aspirin and if they had taken non-aspirin NSAIDs, such as ibuprofen, once a week or more at any point in their life for at least a month.

Participants were considered regular users of aspirin or non-aspirin NSAIDs if they took two or more pills a week for at least one month. Non-regular users were those who took fewer pills.

The study found regular users of non-aspirin NSAIDs reduced their risk of Parkinson’s disease by as much as 60 percent compared to non-regular users and non-users. Women who were regular users of aspirin reduced their risk of Parkinson’s disease by 40 percent, especially among those who regularly used aspirin for more than two years.

“Our findings suggest NSAIDs are protective against Parkinson’s disease, with a particularly strong protective effect among regular users of non-aspirin NSAIDs, especially those who reported two or more years of use,” said Wahner. “Interestingly, aspirin only benefited women. It may be that men are taking lower doses of aspirin for heart problems, while women may be using higher doses for arthritis or headaches.”

“It’s possible the anti-inflammatory agent in NSAIDs may contribute to the observed protective effect of the drugs, but the exact mechanism isn’t clear and further research is needed,” said the study’s principal investigator Beate Ritz, MD, PhD, with UCLA School of Public Health.

This research was published in the November 6, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

The study was supported by grants from the National Institutes of Health, the National Institute of Environmental Health Sciences and the American Parkinson Disease Association.

Source: http://www.sciencedaily.com/releases/2007/11/071105164504.htm

Deep Brain Stimulation Enables Man To Continue His Passions

Monday, November 12th, 2007

Jon Smith was happily living his life when he was diagnosed with Parkinson’s. He was then forced to make a decision that could either give him his life back or take it away.

In June of 2006 we introduced you to this Mishawaka man, an artist and art teacher, who after fifteen years of living and working with the terrible tremors of Parkinson’s disease, had to give up his passion.

No longer able to work, drive, feed himself or paint, uncontrollable shaking took over the canvas of Jon’s life.

He decided on a drastic step—to undergo a delicate brain surgery called Deep Brain Stimulation. A number of electrodes would be placed in Jon’s brain.

It would take two surgeries spanning several hours, performed by South Bend neurosurgeon, Dr. Robert Yount.

Said Yount, “We’re targeting an area called the subthalamec nucleus, which actually inhibits the activity of that nucleus, that controls many of the symptoms of Parkinson’s disease.”

And Jon needed to be awake for this delicate surgery. But when the stimulator was finally tested, Jon’s tremors were virtually gone. But that was just a test.

Two weeks later Jon visits his neurologist who would turn the stimulator on for good. Would it work?

Less than 24 hours later we found Jon in the quiet of his backyard, putting his brush to canvas, working on a painting he had wanted to finish for years. And that unfinished painting Jon was working on in his backyard, is now truly a work of art.

Jon moved to a different home about a year after his surgery, but is still surrounded by his beautiful paintings and stained glass. Recalling the surgery he underwent nearly 18 months ago, “I was at a desperate crossroads and I just decided I was going to put myself in the hands of the surgeon and God.”

Well, both the surgeon and god came through. Jon today is not shaking at all.

worth the surgery? Yes, i would do it again in a minute because the shaking just limited my ability to do anything.

Jon’s ability has returned to continue painting and creating stained glass, and even his newest craze–bugs. Gifts he says he “bugs” his neighbors with!

“It’s very therapeutic making those,” he says, “I sit here all night and make those and time just flies.”

Jon admits that just once after surgery he was tempted to see whether his shakes would return. So he followed through on his curiosity.

“I turned it off and in about ten seconds I just started quivering again. So I know it’s working. I just feel most comfortable with it on all the time.”

And when you can go from shaking hands to a steady brushstroke, it is no small miracle.

“It was like riding a bicycle,” he explains, “or better than riding a bicycle, because my hands just knew what to do. My hands already knew what they had to do. I just held steadily onto the brush and I could move it wherever I wanted it to move.”

For fifteen years this artist could not paint, and since his surgery, he has seen his neurologist just once.

“I called him up and said, ‘I need a checkup, I need my tires rotated my oil changed.’ I had a tune up once this left hand began to shake a little, so he adjusted and now I am even, I’m balanced.”

His hands are balanced, but he suffers one side effect. His legs aren’t as strong as they used to be. Neurosurgeon Dr. Robert Yount says it is one of the possible side effects patients are warned about.

“The goal is to reduce the tremors in the arms, that’s the most disabling thing and sometimes in order to do that you lose a little bit with balance.”

Dr. Yount has performed this same surgery on roughly eight patients since Jon and most get the relief that most of us take for granted.

“For many patients,” Yount says, “they’re happy just to be able to eat soup with a spoon or be able to write their name or fill out a check.”

Jon can do that and more, so losing his balance is something he accepts with humor.

“I tell everyone I had to give up ballet and drag racing.”

But Jon has taken up teaching again. He has even published a book called Paper Knot Animals.

Paper knot art—inspired long ago by some first graders who could not tie their shoes or make a tail for a kite, so he taught them to tie paper knots and create art.

What’s that saying about “art imitating life?”

“You know the other day I thought about that and it is unreal. Because it just had taken so long. 15 years from slow to exaggerated and it’s just unreal that it’s gone, it’s gone.”

And in its place is the signature of an artist who knows what it is like to lose the ability to create, and the gratitude of an artist whose very frame of reference is a work of art.

Source: http://www.wndu.com/mmm/headlines/10963956.html

Dextromethorphan, BMY-14802 Treats Dyskinesias in Parkinson’s Disease

Friday, November 9th, 2007

I think cough medicine has to be one of the worst tastes known to humans, yet, for some, it must be endured to overcome the common ails of the common cold. I almost gag at the remembrance of the awful taste of that medicine.  From the looks of recent research it looks like we may be using it a little bit more for something unrelated to the common cold, treatments of dyskinesias, involuntary movements that progress over time with Parkinson’s disease. 

Science Daily, an online journal, recently announced, “Dextromethorphan, used in such cold and flu medications as Robitussin, Sucrets, Triaminic and Vicks, suppresses dyskinesias in rats, researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center found. Dyskinesias are the spastic or repetitive motions that result from taking levodopa, or L-dopa, over long periods.”  Now for those of you with disapointment that such a discovery comes through the door of cough medicine may be relieved to know that another compound, BMY-14802, has been found to be even more effective in treating dyskinesias in Parkinson’s.

“BMY-14802, a drug previously tested in people with schizophrenia and found to be safe — although not effective in treating schizophrenia symptoms — suppressed dyskinesias in rats more effectively than dextromethorphan did, suggesting that BMY-14802 might work to block dyskinesias in people with Parkinson’s.”

Currently BMY-14802 is in the works of being patented and will soon be used to test on people with Parkinson’s disease.  We will be tracking the tests and results that come from it so that we can get that information out to you as it happens, regardless of how bad I hate cough medicine (I’m definitely crossing my fingers for the BMY-14802.

Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson’s

Wednesday, November 7th, 2007

In many circles aspirin is hailed as the drug of the century.  It is known to reduce some heart disease, prevent
(to a point) alzheimer’s
, and now it’s stated that it can decrease the risk of Parkinson’s disease. 

A recent study published by the University of Los Angeles continues to support the theory of nonsteroidal anti-inflammatory drugs in protecting against Parkinson’s disease.  The study took over 500 hundred people in three different counties in California.  The control group received nonsteroidal anti-inflammatory pills (aspirin) twice a week, while the other group didn’t use a nonsteroidal anti-inflammatory drug.  The group that took the aspirin were at a 40% decreased risk of Parkinson’s than the other group who didn’t take aspirin.  Although these findings are significant there are further studies that need to be administered to more fully prove the aspirin theory.

Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson’s Disease

Wednesday, November 7th, 2007

A recent study at UCLA continues to add to the growing research of the effectiveness of nonsteroidal anti-inflammatory drugs in protecting against Parkinson’s disease.  The research was centered around just over 500 particpants from 3 different counties in California.  The researchers found that those who took nonsteroidal and anti-inflammatory drugs (aspirin) twice a week found that there was about a 40% protective effect than those who took non-aspirin nonsteroidal anti-inflammatories.  Although this study supports the aspirin–Parkinson theory well there still needs to be more studies to fully support this theory.  To read more about this study please click here.

Aspirin, in many circles, is known as the drug of the century.  Not only does it serve as an anti-inflammatory, a Parkinson’s protector, but also as a treatment against Alzheimer’s disease.  Someone needs to nominate this drug as one of the greatest drugs/things to ever come to market. 

Brain Pacemaker Inhibits Decisions

Friday, November 2nd, 2007

Past research has shown that some drug treatments for Parkinson’s inhibit some decisions. The research relates that people under such treatments have a hard time learning from their experiences. The Associated Press relates the following, “Research published Thursday found another treatment, a pacemaker-like brain implant, can trigger a completely different kind of impulsiveness. How different? The drugs leave a subset of patients unlikely to learn from bad experiences, like a losing poker hand.”

The brain implant doesn’t hinder learning. In contrast, those patients can make hasty decisions as the brain loses its automatic tendency to hesitate when faced with conflict, University of Arizona researchers reported online in the journal Science.

There have been many people out there that love the pacemaker route, many tout it being the greatest thing in their life since sliced bread. It’s important to do your research on such treatments. We would love to hear about anyone else’s experiences in regards to this type of treatment.