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Archive for March, 2008

Never Surrender to Parkinson’s Disease

Friday, March 28th, 2008

When long-time Westport resident Paul Green, 84, learned that he had Parkinson’s Disease, the first words he thought of were those of his life-long hero, Winston Churchhill.

“We will fight in the beaches, we will fight in the streets. We will never surrender. Never!” This vow inspired Green to combat the daily assault he would face to stave off the cumulative and debilitating effects of his disease.

Twelve years later, despite the onset of tremors and other symptoms that have invaded his life, Green has fully embraced a physically and mentally active lifestyle that he believes is the key to fighting Parkinson’s.
“Some people are waiting for a cure. I believe we can’t afford to wait,” he said in an interview this week.

Green has just started a not-for-profit corporation called “Never Surrender to Parkinson’s Disease” in order to more effectively spread his message about how to fight the disease. Interested persons are invited to attend the organization’s first fundraiser at the Saugatuck Rowing Club in Westport on Friday, April 4.

Calling his message, “One man’s strategy to battle Parkinson’s,” Green readily admits that traditional physicians still rely heavily on pharmacology to help victims of the disease, but he says that individuals can fight in other very important ways to help themselves.

“There is going to be a cure, but what do you do in the meantime?” Green said. “You have to live your life to the fullest extent possible, and believe me, I am.”
“The key is exercising the body vigorously and keeping the mind active,” he said. A charter member of the Saugatuck Rowing Club, Green is a committed rower, sharing a double with his buddy Andy Pettee or rowing in a single every day, weather permitting. With some assistance, he still carries his scull out to the water and back, fighting daily to ward off symptoms of poor balance, stiffness and weakness. Either by rowing on the Saugatuck, or by working out indoors, he gets his heart rate up daily.

After voracious reading and much personal contact with physicians and experts, he firmly believes that physical exercise and keeping the mind alert are critically important to increase the blood flow to the brain.
“The brain is not set,” said Green. “It has elasticity; whatever you do has a chance of rewiring the brain.”
In addition to the daily vigorous exercise, Green does ballroom dancing, takes Pilates, and has regular massages to fight muscle loss.

He also does voice exercises when alone in his car to combat weakening of his voice.
The physical fight is only half the battle. Many with Parkinson’s Disease are prone to depression. For that, Green encourages a program of socialization and mental challenge.

“If you keep the mind active, at least you have a fighting shot,” he said.

Green is studying Japanese, plays chess, is a member of a book club and loves to socialize with people of all ages. He is passionate about the Saugatuck Rowing Club, where he is steeped in an active, healthy environment filled with people of all ages, and says, “When I’m here, I feel great. It’s so important to be active and get out of the house.” He also volunteers at Norwalk Hospital, where he works with in the emergency room and feels like a valuable member of a team. “My message is one of hope,” said Green. “You are not a victim that cannot take action. With hope you fight to maintain your independence. Right now I am doing everything I’ve ever done except drive at night. I do have symptoms, but they don’t stop me.”

Green finds that his concept of “aerobics for the body and neurobics for the brain” is getting more and more support from the medical community, and he posts important updates on his new website www.nevahsurrendah.org.
He quotes from “A User’s Guide to the Brain,” by Harvard medical school professor, Dr. John Ratey.
“As with our muscles, we can strengthen our neural pathways with brain exercise,” he said. “Or we can let them wither. The principle is the same. Use it or lose it!”

Another recent article in Harvard Magazine, entitled “The Power of Exercise,” also confirms Green’s belief that the greatest beneficiary of vigorous exercise is the brain.

“This article confirmed that I could spread the word to people to exercise as much as they can.” If you are depressed you believe you can’t do anything. But we can all do something. That’s the big message.”
The reason Green started his non-profit company, “Never Surrender to Parkinson’s, Inc.” is to spread the word of hope as widely as possible. Funds raised at next week’s fundraiser will be used to support the website, start a newsletter, create a board of directors and facilitate Green’s intention to give talks on his method of fighting Parkinson’s. He quotes Churchill again, “Give us the tools and we will do the job.”

Source: http://www.zwire.com/site/news.cfm?BRD=1654&dept_id=57102&newsid=19428593&PAG=461&rfi=9

Cloning Treatment Could Be a Big Boost

Monday, March 24th, 2008

SCIENTISTS may soon be able to grow a patient’s own brain tissue to repair damage caused by Parkinson’s disease, according to a study that marks a milestone in efforts to find a cure.

Researchers saw an improvement in the condition of mice that had Parkinson’s after cloned cells were grafted on to their brains.

It is the first time “therapeutic cloning” has been used to treat the devastating disease. Cloned cells are so useful because they are genetically identical to the patient, and are not rejected.

Although carrying out the procedure on humans is a long way off, in the short term scientists hope to test new drugs on brain cells from Parkinson’s patients grown in the lab.

Parkinson’s affects about 120,000 people in Britain, with 10,000 new cases diagnosed every year. It robs sufferers of the ability to walk and even eat. As the disease progresses, higher doses of drugs are required, leading to side-effects that include involuntary movements.

The study, published today in the journal Nature Medicine, suggests that the same method of cloning used to create Dolly the sheep can be used to grow a patient’s own brain tissue and repair damage done by the debilitating disease.

The principle is to create specific nerve cells, producing the signalling chemical dopamine, which are destroyed by Parkinson’s. An American-Japanese team succeeded in using the “nuclear transfer” cloning method to turn mice tail cells into embryonic cells, and then into the desired nerve cells.

The team, Dr Lorenz Studer, Dr Viviane Tabar and colleagues at the Memorial Sloan-Kettering Cancer Centre in New York, together with colleagues in Japan, derived 187 lines of nerve cells from 24 mice with Parkinson’s.

The mice that received a graft of 100,000 neurons derived from their own cloned embryos exhibited brain improvements, according to studies of their movements and behaviour.

It is the first time that the “Dolly method” has been used successfully to treat disease in the same animals from which the cells were derived.

Dr Kieran Breen, director of research and development at the Parkinson’s Disease Society, said: “This is an exciting development, as for the first time we can see that it may be possible to create a person’s own embryonic stem cells to potentially treat their Parkinson’s. Researchers in this area now need to carry out more studies to satisfy safety concerns.”

The team concluded that there was “considerable therapeutic potential for the future”.

For the procedure to work with humans, the scientists would need to create embryonic cells. At the moment the main method is to use human eggs, which is highly controversial. However, a method of turning adult cells into embryonic cells has been developed that could be more acceptable.

Source: http://www.therapeuticsdaily.com/news/article.cfm?contentValue=1754872&contentType=sentryarticle&channelID=30

Deep Brain Stimulation Study

Wednesday, March 19th, 2008

I am following Kate Kelsall’s lead on this. I am finding this hard to believe as well. Please forward this to your Neurologist, Movement Disorder Specialist, and other professionals you work with.

PARKINSON’S DISEASE NEWS
From Viartis
16th March 2008 – New research

How Many People Are Suitable For DBS Surgery?

Parkinsonism Related Disorders [2007] 13 (8) : 528-531 (Morgante L, Morgante F, Moro E, Epifanio A, Girlanda P, Ragonese P, Antonini A, Barone P, Bonuccelli U, Contarino MF, Capus L, Ceravolo MG, Marconi R, Ceravolo R, D’Amelio M, Savettieri G.)

See complete abstract.

DBS is a surgical method of treating Parkinson’s Disease that uses electrodes implanted into the brain. For more information, go to Deep Brain Stimulation. Researchers estimated the percentage of people with Parkinson’s Disease that are suitable for subthalamic nucleus (STN) deep brain stimulation (DBS). They used the Core Assessment Program for Surgical Intervention Therapies in PD (CAPSIT-PD), which examines patients in a “practically defined off state” after overnight 12-hour drug withdrawal and again in the on state after their usual morning dose of L-dopa. They found that out of 641 Parkinson’s Disease patients only less than 2% fulfilled strict criteria in order to be eligible. When the researchers applied more flexible criteria, the percentage of eligibility increased. Yet the number of those that were eligible was still less than 5%. Most patients – 60% of them – were ineligible because they did not satisfy multiple questionnaire items. Items related to disease severity were responsible for the largest number of those people being excluded from eligibility.

Milk, Does it Do a Mind Good?

Monday, March 17th, 2008

milk.jpgA recent study from the American Journal of Epidemiology has me asking the question if Milk does a mind good?  The study concluded that consuming dairy products boosts the risk of Parkinson’s disease.  The study surveyed 57,689 men and their dietary habits and found a 60 percent increase in the risk of Parkinson’s disease.  Processed milk accounted for most of the dairy.

I have been drinking processed milk for years now, probably up to 20 years now and these studies are enough to make me quit the processed.  Processed milk is milk that has gone through and been processed of microorganisms that may be living in the milk it also cooks the milk and strips of it healthy aspects of it as well.

To learn more about this study you can go to: http://www.naturalnews.com/022845.html

GDNF and Parkinson’s Disease

Friday, March 7th, 2008

GDNF is a naturally occurring growth factor that proved capable of protecting and promoting the survival of motor neurons in animal studies. A growth factor is a growth inducing protein found in the human body. There was a growing interest in these naturally occurring proteins that have a supportive, reparative or protective role for motor neurons in animals.  The video below show examples of those who have been treated by GDNF:

Dancing with Parkinson’s Disease

Thursday, March 6th, 2008

We have written quite  a bit about the importance of exercise as well as activities that take coordination, studies have found exercise that takes coordination can help improve the symptoms of Parkinson’s disease.  We have recently written about dancing and how it has helped many people.  Here is one article that discusses dancing that I found enjoyable and informative.

Carl Ewert, with a grin acknowledging the unlikelihood of his executing all the twirls, hops and dips the dance requires, is waiting for a jitterbug. “The jitterbug’s my dance,” he says.

But when a merengue comes up, Ewert, 88, of Surprise, needs no coaxing. Red Nebraska Huskers cap planted securely atop graying hair, he sets aside his walker and joins more than a dozen others warming up to dance at Shepherd of the Desert Lutheran Church in Sun City.

There are no wallflowers at these ballroom-dance classes for people with Parkinson’s disease.

On a recent afternoon, teacher Kathleen Henry plays Latin-flavored music to lure people to the dance floor, where they practice grapevine steps, holding hands in a circle for stability until they’re ready to dance in pairs.

“Turn your shoulder and hip slightly so you don’t get your feet tangled up,” she says.

Her classes, low-key and nurturing, are offered through the Muhammad Ali Parkinson Center, part of the St. Joseph’s Hospital and Medical Center campus in Phoenix.

Dance may seem an unusual choice for supplementing treatment of Parkinson’s disease, a progressive neurological disorder marked by tremors, slowed movements, stooped posture, stiffness and balance difficulties.

“People with the disease ask me, ‘Why can I dance better than I can walk?’ ” says neurologist Abraham Lieberman, director of the Muhammad Ali center. “Well, when you dance, your spine is straight without your thinking about it, you’re using both sides of your body equally and you’re following a rhythm and a pattern.”

The activity is one more tool – a pleasurable one, in this case – for improving management of the incurable disorder, he says.

Lieberman says Parkinson’s strikes about 3,500 people out of a million. Most of them are 60 and older, their symptoms developing when nerve cells in a section of the midbrain die or are impaired and can’t secrete dopamine. Dopamine is a naturally produced chemical that transmits signals to the brain’s movement-control centers.

Ewert, diagnosed with the disease in 1988, played right guard for the University of Nebraska Cornhuskers football team in 1937 and ‘38 and worked as a contractor until his retirement in 1982.

Now, he says, “I’m lost without my walker.”

You’d never know it to see him scoot across the floor to rumba and salsa music, dancing with another patient, Elsa Howard, 63, of Phoenix, or her sister, Cheryl Krause, who drives Howard here and stays to dance. Extra partners, including church volunteer Ladonna Hardt, fill in as needed so everyone has a full dance card.

Francis MacDonald, 69, an Avondale resident who has had Parkinson’s for almost 10 years, tries new steps with others who share his disorder. But he reserves most of the dances for his wife, Elaine, and he sings Everybody Loves Somebody Sometime to her as they do the box step.

“It’s amazing how the music sustains him, even when he’s not feeling well,” Elaine says during a break for the apple cider and cookies that instructor Henry brought. “When he’s not dancing, he usually can’t move like this.”

Better quality of life

John O’Donnell, 66, struggles a bit to keep the beat to the music – maybe playing 18 holes of golf before class wasn’t the best idea – but Karen, his wife, tells him not to worry about that for now.

Just try this, she says: “Quick, quick, slow. Quick, quick, slow.” She brushes back his hair, mussed by their fancy footwork and their spins, and they laugh about his progress.

“Once today I actually started on my left foot, like I’m supposed to,” the Sun City man says.

But dancing, however wrong-footed, is helping him resist the Parkinson’s-related tendency to curl his body inward, he says. He and his wife are having fun together, too, and that’s as important as the exercise.

Brings back joy

Darolyn O’Donnell, recreation therapy coordinator for the Muhammad Ali Parkinson Center and no relation to John and Karen, says dancing can temporarily dissolve spouses’ (or relatives’ or friends’) patient-caregiver relationship and restore their pre-Parkinson’s partnership.

Dancing – and laughing about it – also stimulates the release of protective endorphins in the brain, Darolyn O’Donnell says.

As she takes a few turns around the dance floor with class participants, O’Donnell sees how dance makes their movements easier and their quality of life better.

Lily Bell starts tentatively but with the innate grace of a longtime dancer. Confidence building, she performs a slow cha-cha to Stormy Weatherwith Starr Fetzer, her friend since 1979.

Like many Parkinson’s patients, Bell, 63, of Phoenix, sees her doctor regularly, does recommended exercises, follows a healthful diet and takes prescribed medicine for her condition. But these classes are bringing one of her greatest joys back into her life, she says.

Until the disease struck four years ago, she loved going dancing with her husband, Gary, and Fetzer every chance she got.

“When Gary got tired from taking turns dancing with both of us,” Bell says, “Starr and I would dance together while he rested.” With Gary at work during the classes, Starr is once more filling in as Lily’s dance partner.

Neurologist Lieberman, who also is movement-disorders department chief for Barrow Neurological Institute at St. Joseph’s, says physical therapy alone is not enough for patients with Parkinson’s disease. To relieve symptoms consistently, they need to follow through with regular activity of their own.

“But if I say I want you to exercise,” Lieberman says, “it’s another chore. If I tell you to dance for at least half an hour a day, with a partner and to music, you’ll do it.”

The benefits can be unexpected. Dance requires what Lieberman calls “a General Patton stance.” A straight spine keeps the head and chin lifted, and that makes speaking and chewing easier for people with Parkinson’s, he says. It also allows their lungs to expand more fully and their leg muscles to propel them better.

Dick Varnau, 86, already is convinced of the value of staying active. Before this day’s class, he walked a mile, exercised for an hour, picked tangelos at his home in Sun City West and scooped leaves out of the swimming pool.

But he has energy to spare for a few dances with his wife, Joan, the love of his life for 61 years. “She’s always easy to dance with,” he says as today’s class ends.

Before Dick and Joan turn in tonight, they say they will – as is their daily habit – play three rolls of music on their electric player piano. And they might even make time for another dance.

Source: http://www.azcentral.com/arizonarepublic/arizonaliving/articles/0304parkinsonsdance0304.html

Kyowa Hakko Parkinson’s Drug Isn’t Approved by FDA

Monday, March 3rd, 2008

By Kanoko Matsuyama

Feb. 28 (Bloomberg) — Kyowa Hakko Kogyo Co., the drugs arm of Kirin Holdings Co., Japan’s biggest brewer, said U.S. regulators didn’t approve its new medicine for Parkinson’s disease because more evidence is needed to show that it works.

The Food and Drug Administration said Kyowa Hakko’s filing for the medicine, known as istradefylline or KW-6002, wasn’t approvable and asked for more data to support its use in combination with levodopa, an older treatment, according to a statement by the Tokyo-based company today.

“We will carefully look into the requests from the FDA and closely communicate with them about the plan going forward,” said Kyowa Hakko spokesman Yasuhiro Yamamoto in a telephone interview today.

One of the most common progressive neurological diseases, Parkinson’s disease will, by 2015, affect 3.6 million people in Europe, the U.S. and Japan alone, an increase of 21 percent over 10 years, according to Orion Oyj, the Finnish producer of Parkinson’s disease treatments. The value of the market will rise 79 percent to $3.4 billion, the company said in November.

Kyowa Hakko shares fell 7 yen, or 0.7 percent, to 1,032 yen on the Tokyo Stock Exchange today. Shares declined as much as 2 percent to 1,018 yen the announcement.

FDA expressed concern that efficacy findings from patient studies may not support clinical utility of istradefylline, and also asked for more information on the drug’s action in patients, the statement said.

Novel Action

The experimental medicine uses a novel mechanism of action that disrupts adenosine receptors, which can slow metabolic activity in the brain.

Kyowa Hakko ended the joint partnership with Roche Holding AG, the world’s biggest maker of cancer medicines, to develop istradefylline in January 1999 after patient studies indicated that the compound may exacerbate the side effects of other drugs taken with it.

Kyowa Hakko suspended U.S. trials of the drug because of safety concerns in 2003 and delayed filing an application for the experimental medicine with the U.S. regulators in 2006.

The company submitted its application to the FDA last April, the same month that said it stopped seeking approval to sell the drug as a mono therapy.

Source: http://www.bloomberg.com/apps/news?pid=20601101&sid=a1kzhOGoQBRo&refer=japan