Home Contact

logo

Family

Links:






Archives:


Newsletter:

Register for our Free monthly newsletter to receive timely updated information about Parkinsons Disease directly in your email.
Email
First Name
Last Name
Zip Code

Categories:



Register for our FREE monthly newsletter to receive timely updated information about Parkinsons Disease directly in your email.

Archive for April, 2008

Deep Brain Stimulation for Severely Depressed

Tuesday, April 29th, 2008

Studies have showed that those who have Parkinson’s disease are much more likely to suffer from depression. Not too long ago I wrote a blog about the connection of Parkinson’s disease and depression. For those who had advanced in the later stages of Parkinson’s disease (which many of them suffered from depression) deep brain stimulation was used to help reduce some of the symptoms of Parkinson’s disease.

As of late researchers have noticed that deep brain stimulation has cut people’s depression by 50% for about half of the people that are treated. For the last twenty years deep brain stimulation has been able to help people that have suffered from Parkinson’s disease, for some it does miracles in reducing the affects of Parkinson’s disease. Now medical professionals are using deep brain stimulation for those who suffer from depression. Deep brain stimulation is accomplished by placing electrodes in parts of the brain that seem to be malfunctioning. When the electrodes are in place they emit tiny, adjustable, electrical shocks that help stimulate the parts of the brain that may not be functioning appropriately.

I love it when certain sectors of medical research are able to help other sectors. I feel like the medical world is much smaller then we make it out to be, at least that’s what I think. I feel like we delineate medical stuff too much and miss out on the drugs, medical practices, and knowledge that can overlap between medical sectors, such as depression and Parkinson’s disease. (more…)

Three New Ways to Diagnose Parkinson’s Disease

Friday, April 25th, 2008

A few years ago early diagnosis of Parkinson’s disease was unheard of, diagnosis mostly came when the shaking and tremors started and for many it took months to figure out what the shaking and tremors were all about.  Today, thanks to technology and medical research, we are able to diagnose Parkinson’s disease sooner and help slow the progression of it.

Recent research has suggested that there may be a number of ways to catch Parkinson’s disease at its onset or earliest stages.  One way that Parkinson’s disease may be caught early is through a smell test.  Some research suggests that the symptoms of late stage Parkinson’s is preceded by loss of smelling power.  The smell test tests for 40 common odors and has been used to detect the first signs of neurodegenerative disorders.

People with a normal sense of smell who take the test can usually identify around 35 odors correctly. Parkinson’s patients typically can only identify 20 or less.

Another test that has received a lot of press as of late is a blood test that can possibly diagnose Parkinson’s disease.  The makers of the blood test also claim that the test can diagnose whether a person may have Parkinson’s disease, Alzheimer’s disease, Lou Gehrig’s disease, or if they are disease free.

Today I learned of another way that researchers can possibly diagnose Parkinson’s earlier and that’s through magnetic resonance imaging (MRI).  Magnetic resonance imaging is different from computed tomography scan (CT scan).  A CT scan uses ionizing radiation while magnetic resonance uses radio waves to change the magnetic alignment causing the hydrogen atoms in a persons body to produce a rotating magnetic field detectable by the scanner.  The signals created by this process build-up enough information to create an image of the body.

MRIs enable medical professionals to view the white matter–the nerves that are message transporters to various parts of the brain–and grey matter which receives and interprets those messages.  Researchers noticed that those who had Parkinson’s disease showed reduced grey matter compared to those who didn’t have Parkinson’s disease.

Many of these diagnostic tests are in their early stages and there are still evaluations that need to go on, but we’ll keep you updated to the progress of these tests.

Urate Levels and Parkinson’s Disease

Monday, April 21st, 2008

By Will Dunham

WASHINGTON (Reuters) – Parkinson’s disease worsens at a slower pace in people with naturally higher levels of a compound called urate in their blood, suggesting a possible new way to help fight the incurable ailment, researchers said on Monday.

Urate, the salt form of uric acid, is a prominent component of blood, urine and spinal fluid. It also is a powerful antioxidant that may protect cells from damage and its antioxidant potency rivals that of vitamin C.

The researchers looked at data from a previously conducted study of about 800 people with early Parkinson’s disease who were tracked for about two years.

Patients whose urate levels were in the highest 20 percent of all the study participants were half as likely as those with levels in the lowest 20 percent to have their disease progress to the point they needed medication to treat their symptoms.

In addition, brain scans showed evidence that those with higher urate levels also lost the fewest dopamine-producing neurons, the type of brain cell affected by the disease.

“We found that higher levels of urate among people with early Parkinson’s disease is associated with a slower rate of Parkinson’s progression,” Dr. Michael Schwarzschild of Massachusetts General Hospital, who helped lead the study, said in a telephone interview.

The findings appear in the journal Archives of Neurology.

Parkinson’s disease is caused by the destruction of brain cells that produce the neurotransmitter dopamine, which normally sends signals that help coordinate the body’s movements. It typically develops after age 60 but can appear earlier in some people.

Symptoms can include trembling, muscle rigidity, difficulty walking, problems with balance and slowed movements. The disease gets worse over time and there is no cure but some treatments can help control symptoms for a time.

NEW RESEARCH

Other recent research showed healthy people with naturally higher levels of urate had a reduced risk of developing Parkinson’s disease. Schwarzschild said those findings along with the new results involving Parkinson’s patients indicate the urate could inspire new drugs intended to slow the disease’s progression.

Coinciding with the publication of the new findings, the Michael J. Fox Foundation announced a $5.6 million grant to fund a clinical trial involving about 90 patients with early Parkinson’s to explore whether a chemical called inosine, which is a building block of urate, may be useful to slow the progression of the disease.

The foundation is named after the actor who has the disease. Schwarzschild will head the new study.

While urate appears to hold promise in the fight against Parkinson’s disease, Schwarzschild cautioned against taking it in supplement form in an attempt to control the condition. He emphasized that high levels of urate are associated with the development of two painful conditions — gout and a certain kind of kidney stones.

“Outside of a well-monitored clinical trial, it wouldn’t be a safe thing for patients with Parkinson’s or the general public to be trying to do — at least with the information we have now,” Schwarzschild said.

The study whose data led to the new findings focused on an experimental compound that failed to slow the progression of Parkinson’s disease in the patients.

Source: Reuters

Sleep Disorder Precedes Parkinson’s Disease

Friday, April 18th, 2008

By Martha Kerr

NEW YORK (Reuters Health) – Individuals who exhibit behaviors related to the loss of normal eye movements associated with rapid eye movement (REM) sleep are at increased risk of Parkinson’s disease and mild dementia, a Mayo Clinic researcher reported at the 60th annual meeting of the American Academy of Neurology, being held this week in Chicago.

The findings come from a series of studies conducted by Dr. Bradley Boeve and colleagues involving 765 residents of Olmstead County who were between the ages of 70 and 89. The subjects were assessed for anxiety, depression, apathy and probable REM sleep behavior disorders based on a series of questionnaires.

REM is the sleep phase in which dreams occur. Periods of REM are variable in length, but normally represent about 20 percent of a typical night’s sleep. Interruption or lack of REM sleep can cause a variety of symptoms such as frequent nocturnal wakening, daytime sleepiness, and restless movement.

The overall prevalence of REM sleep behavior disorders in this population was 8.0 percent. “These are ostensibly cognitively normal older people in the community” and a prevalence of 8.0 percent is high, Boeve told Reuters Health, “especially if it is a risk factor for dementia.”

There was a significant relationship between REM sleep behavior disorders and anxiety and apathy, but no significant link was found between REM sleep behavior disorders and depression.

“We see some nice supporting data of an ascending disease,” Boeve noted.

“REM sleep behavior disorders appear to start at the south end of the brain stem and appear to ascend,” he explained. “The next site higher in the brain stem is the emotions, and this component of the syndrome appears to come later, after there has been a history of violent nightmares. Next is the motor movement center, and the highest is the cerebral cortex and cognitive defects.”

Boeve pointed out that REM sleep behavior disorders appear to be associated with Parkinson’s disease and dementia.

Some patients will respond to treatment with levodopa, he said. Clonazepam can also be effective for a large number of patients and over-the-counter melatonin works about half of the time. “Patients still dream, but they have fewer violent nightmares.”

Source: Reuters

Training with Parkinson’s Disease

Monday, April 14th, 2008

LOS ANGELES — On his worst days since he quit fighting, trainer Freddie Roach’s left arm trembles, his speech is slurred and he is easily fatigued.

He blames boxing for his Parkinson’s disease, but he still steps into the ring to work with others because he loves the sport and believes it keeps his condition from getting worse.

“I think what I do really fights it,” he said. “Hand-eye coordination, catching punches with the mitts and so forth, I think that’s what keeps me from getting worse.”

Boxing is Freddie Roach’s life. It landed him in his father’s good graces as a boy, kept him busy for 10 years as a professional fighter, and made him a hugely successful and rich trainer. He loves the people, the strategizing, the globe-trotting.

Even after dealing him the blow of a chronic illness, you won’t hear any hint that the sport betrayed him. He wants to keep doing what he does for the rest of his life.

“When it’s time for me to retire and I’m not functional, I will,” he said. “I don’t like to be in the way. The Parkinson’s, some people tell me I’m going to get worse, it’s part of the symptoms of it. But so far I haven’t.”

The 48-year-old Roach has trained champions like Mike Tyson, Oscar De La Hoya, James Toney and — his proudest accomplishment — Manny Pacquiao. Next up: Bernard Hopkins, who takes on Joe Calzaghe April 19 in a light heavyweight bout in Las Vegas.

A millionaire, Roach lives alone in a sparsely furnished, two-bedroom apartment that adjoins the boxing gym

he owns on the second floor of a Hollywood strip mall. His alarm clock is the sound of punches on the other side of the wall.

He has much less severe symptoms than Muhammad Ali, whose Parkinson’s has progressed to the point he can barely speak. The cause of the neurological disorder is unknown, but some experts believe boxers are at risk because their bodies take such a pounding. Roach says Mayo Clinic doctors blame boxing for his ailment, but acknowledge there is no proof.

Roach takes pills three times a day that have helped, as have the skills required of a trainer. He stands firmly in the ring while absorbing Hopkins’ solid punches to the pads he holds.

Hopkins says he struggles to hear his trainer’s slurred speech, but the fighter with a 48-4-1 pro record calls Roach one of the best in the business. He points to some of Roach’s marquee boxers — himself included, of course.

“It’s the handicap that didn’t affect his training,” Hopkins said.

Roach was born in Dedham, Mass., the fourth of seven children. His father, the late pro boxer Paul Roach, gave the five boys gloves for Christmas. Freddie fought the first of about 150 amateur bouts when he was 6 years old.

“If you came home with all D’s on your report card, no problem,” said Domenic “Pepper” Roach, an older brother. “School didn’t count, didn’t matter. Boxing was everything.”

Roach was 41-13 as a pro, fighting as a super bantamweight and lightweight, but missed his goal of a world title. When Eddie Futch, his trainer and mentor, suggested he quit, he ignored the advice and fought five more bouts. He lost four of them.

“I just wasn’t ready. When he asked me to retire, I just couldn’t see it,” Roach said. “I should have quit.”

Roach finally quit in 1987 and worked briefly as a telemarketer in Las Vegas before Futch hired him that year to help train. Nick Khan remembers his longtime friend drinking a lot and getting into too many fist fights.

“He found out that without boxing he had nothing,” said Khan, now a Los Angeles attorney. “He sort of had a realization that he needed boxing in his life.”

He was diagnosed with Parkinson’s in 1990, and his money problems persisted.

Roach blew $150,000 in six months after his first big payday as a trainer, Virgil Hill’s 1991 decision loss to Thomas Hearns. Roach bought cars for himself and his mother, but he’s at a loss to explain how it went so quickly, a sobering blow that helps explain why he has become so frugal. He recently splurged on a new Lincoln MKX, but has few other indulgences.

Stem Cells From Skin Treat Parkinson’s Disease

Friday, April 11th, 2008

Just two weeks after a previous similar reporting, Cambridge scientists have reported that they successfully used stem cells that were “reprogrammed” from ordinary skin cells to alleviate symptoms of Parkinson’s disease in rats. Their work was published in the Proceedings of the National Academy of Sciences and shows that reprogrammed cells, also called induced pluripotent stem (iPS) cells, can become functioning neurons when transplanted into the brains of mice and rats.

The team, which was made up by scientists from MIT and Harvard, has transplanted healthy neurons cultivated from reprogrammed stem cells into the midbrains of rats which were previously damaged similarly to the effects of Parkinson’s. The rodents showed significant alleviation of symptoms of brain damage, such as wandering in uncontrollable circles.

“This is the first demonstration that reprogrammed cells can integrate into the neural system or positively affect neurodegenerative disease,” said Marius Wernig, a scientist at the Whitehead Institute for Biomedical Research and lead author of the research, quoted by The Boston Globe.

This approach to obtaining stem cells, the so-called nuclear reprogramming technique, is much more interesting in the long term and has gained momentum recently. While “therapeutic” cloning produces stem cells, the technology involves the creation and destruction of embryos, which is ethically unsound. The stem cells created also run the high risk of being rejected by the recipient’s body. In turn, nuclear reprogramming, creates stem-like cells from the patient’s own cells, avoiding both medical and ethical problems. Dolly’s cloner, Sir Ian Wilmut, also endorsed this technique and declared last year he abandoned the idea of human cloning in favor of nuclear reprogramming.

Two weeks ago, American and Japanese researchers converted skin cells from the tail of the sick animal into the dopamine-producing brain cells they lacked, and grafted the genetically matched tissue back into the same mice. Before being injected with the stem cells, the mice had a number of behaviors common to their disease. Once injected with the cells, mice’s behavior returned to normal. It was after the mice were killed, when the researchers discovered that the neural cells they’d injected had grown and formed connections with other cells.

There’s also a downside to Parkinson’s treatments using stem cells: recent studies show that treatment solutions for Parkinson’s disease must be much improved because some traces of brain damage linked to the disease were found spreading into the transplanted tissue. This suggests that the disease presents an ongoing process which constantly inflicts damage.

Source: eFluxMedia

My Parkinson’s Information

Friday, April 11th, 2008

My Parkinson’s Information is a site that is dedicated to informing people who are affected by Parkinson’s Disease about research, recent studies, and the latest and greatest news about what is going on in the Researching/World of Parkinson’s. We also highlight the lives of people who deal with Parkinson’s disease on a daily basis. As the primary writer of this website I feel very blessed to share with all of you the things that I have learned. I am especially thankful that I get to meet so many amazing people and then write about them.