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Archive for February, 2010

Mirapex ER Approved as Once a Day Drug by the US FDA

Friday, February 26th, 2010

Last Wednesday, Mirapex ER (pramipexole dihydrochloride exteneded-release) was approved by the US FDA as a once a day drug treatment for early Parkinson’s disease. The announcement came from Boehringer Ingelheim in a news release.

Mirapex has been approved for a long time for Parkinson’s disease, actually for more than a decade, but after a clinical study of more than 400 people with Parkinson’s disease approval was given that such a drug could be defined as a once a day drug.

The side-effects remained the same for Mirapex and Mirapex ER which includes dizziness, sleepiness, nausea weakness, constipation, and insomnia.

What is Parkinson’s Disease?

Tuesday, February 9th, 2010

What is Parkinson’s Disease may sound like a funny question at this point, especially considering that I’ve written about everything from PD drugs to specific posts dedicated to people that have been affected by Parkinson’s disease, but I was looking through the search engines under said question and I couldn’t find great information easily, so I’m writing this for two reasons:

  1. To establish some content on the web and search engines that easily addresses said question
  2. To create another place on my website to have this questions answered (the other place to find it is on my Parkinson’s FAQ page)

Parkinson’s disease a degenerative disorder of the central nervous system. It affects 1 in 100 people over the age of 60. On average the disease onset is 60 years old, although 5 to 10 percent will see the disease onset between 30 to 40 years old–like Michael J. Fox.  It occurs when neurons that produce dopamine die off quickly. When a large portion of the neurons that produce neurons die, patients begin to feel the symptoms of tremors, stiffness, and other similar symptoms. Parkinson’s is a chronic and progressive disease, but because each person is different the disease may manifest itself in different ways.

Currently about 1 million Americans have been diagnosed with Parkinson’s disease and about 6 million people worldwide.  Disease symptoms include resting tremor, slowness of movement, postural instability, and rigidity. Tremors are unwanted and uncontrollable movement when a limb is resting and rigidity is abnormal stiffness in a limb. Both of these symptoms probably seem like they contradict each other to a point. These symptoms can be frustrating for someone who has PD because they are so opposite and because they are opposite you would think that you can only have one, but that’s not the case, often they are manifested together.  Symptoms are different for everyone and are manifested differently and often at a different pace than everyone else.

If you’d like to learn more I would suggest visiting www.michaeljfox.org

The Michael J. Fox Foundation Does it Again, $2.8 Dollars For Parkinson’s Disease Biomarkers

Friday, February 5th, 2010

The Michael J. Fox Foundation did it again, they are awarding $2.8 million in awards to 13 researchers or institutions that are moving forward with research or clinical trials of biomarkers. Biomarkers are important because they can be critical to understanding the progression of PD as well as to understand the best therapeutic practices to slow or disrupt the disease.  The identification of biomarkers would also help to provide more definitive outcomes from clinical trials.